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| Cat.No | ACP08956 | Target Name | BCHE |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 29-602aa | Mol Weight | 67kD |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P06276 |
|---|
Uniprot Id
P06276
Target Species
Human
Target Name
BCHE
Target Full Name
Cholinesterase
Target Function
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Target Involvement
Butyrylcholinesterase deficiency (BChE deficiency)
Target Subcellular Location
Secreted.
Target Protein Families
Type-B carboxylesterase/lipase family
Target Tissue Specificity
Detected in blood plasma (at protein level). Present in most cells except erythrocytes.
Target Research Area
Neuroscience
Target Synonyms
Acylcholine acylhydrolase; BCHE; Butyrylcholine esterase; CHE1; CHE2; CHLE_HUMAN; Choline esterase II; Cholinesterase (serum) 2; Cholinesterase 1; Cholinesterase; E1; Pseudocholinesterase; Pseudocholinesterase E1
Target Background
This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine.
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