Recombinant Human Chondroitin sulfate synthase 1 (CHSY1), Truncated

Uniprot Id

Q86X52

Target Species

Human

Target Name

CHSY1

Target Full Name

Chondroitin sulfate synthase 1

Target Function

Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling.

Target Involvement

Temtamy preaxial brachydactyly syndrome (TPBS)

Target Subcellular Location

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted.

Target Protein Families

Chondroitin N-acetylgalactosaminyltransferase family

Target Tissue Specificity

Ubiquitous, with the highest levels in placenta. Detected at low levels in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, adrenal gland, mammary gland, stomach, small intestine, lung and peripheral blood leukocytes.

Target Synonyms

Carbohydrate synthase 1; Chondroitin glucuronyltransferase 1; Chondroitin glucuronyltransferase II; Chondroitin sulfate synthase 1; Chondroitin synthase 1; CHSS1_HUMAN; CHSY; ChSy-1; Chsy1; CSS1; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1; N acetylgalactosaminyltransferase II; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1; N-acetylgalactosaminyltransferase 1; TPBS