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| Cat.No | ACP19053 | Target Name | CHRD |
|---|---|---|---|
| Target Synonyms | CHRD; UNQ217/PRO243Chordin | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9H2X0 |
|---|
Uniprot Id
Q9H2X0
Target Species
Human
Target Name
CHRD
Target Full Name
Chordin
Target Function
Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
Target Subcellular Location
Secreted.
Target Protein Families
Chordin family
Target Tissue Specificity
Expressed at the highest level in liver.
Target Synonyms
CHRD; UNQ217/PRO243Chordin
Target Background
This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined.
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