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| Cat.No | ACP11776 | Target Name | GCM1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-436 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NP62 |
|---|
Uniprot Id
Q9NP62
Target Species
Human
Target Name
GCM1
Target Full Name
Chorion-specific transcription factor GCMa
Target Function
Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development.
Target Subcellular Location
Nucleus.
Target Tissue Specificity
Highly expressed in the placenta. Expressed in trophoblast cells of the villi.
Target Synonyms
Chorion specific transcription factor GCMa; Chorion-specific transcription factor GCMa; GCM 1; GCM A; GCM motif protein 1; Gcm1; GCM1_HUMAN; Gcm1rs1; GCMA; Gcmrs2; Glial cells missing homolog 1; Glial cells missing homolog a; Glide; hGCMa
Target Background
This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.
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