Recombinant Human CHRNA7-FAM7A fusion protein (CHRFAM7A), Truncated

Uniprot Id

Q494W8

Target Species

Human

Target Name

CHRFAM7A

Target Full Name

CHRNA7-FAM7A fusion protein

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Ligand-gated ion channel (TC 1.A.9) family

Target Tissue Specificity

Expressed in hippocampus.

Target Synonyms

CHRFAM7A; CHRNA7-FAM7A fusion protein; CHRNA7-DR1; D-10

Target Background

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.