Recombinant Human Chromatin assembly factor 1 subunit A (CHAF1A), Truncated

Uniprot Id

Q13111

Target Species

Human

Target Name

CHAF1A

Target Full Name

Chromatin assembly factor 1 subunit A

Target Function

Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci.

Target Subcellular Location

Nucleus. Note=DNA replication foci.

Target Protein Families

CHAF1A family

Target Synonyms

CAF 1; CAF 1 subunit A; CAF; CAF I 150 kDa subunit; CAF I p150; CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; CAF1; CAF1A_HUMAN; CAF1B; CAF1P150; CHAF1A; Chromatin assembly factor 1 subunit A; Chromatin Assembly Factor 1 Subunit A p150; Chromatin assembly factor I (150 kDa); Chromatin assembly factor I 150 kDa; Chromatin assembly factor I p150 subunit; DCAF1; hp150; MGC71229; P150

Target Background

Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).