Recombinant Human Chromosome transmission fidelity protein 18 homolog (CHTF18), Truncated

Uniprot Id

Q8WVB6

Target Species

Human

Target Name

CHTF18

Target Full Name

Chromosome transmission fidelity protein 18 homolog

Target Function

Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage.

Target Subcellular Location

Nucleus. Note=Associates with chromatin during S phase.

Target Protein Families

Activator 1 small subunits family, CTF18 subfamily

Target Synonyms

6030457M03Rik ; C16orf41; C321D2.2; C321D2.3; C321D2.4; CHL12; chromosome transmission fidelity factor 18 homolog (S. cerevisiae); Chromosome transmission fidelity protein 18 homolog; chtf18; Ctf18; CTF18_HUMAN; hCTF18; MGC38008; RUVBL

Target Background

This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition.