Recombinant Human Cis-aconitate decarboxylase (ACOD1)

Uniprot Id

A6NK06

Target Species

Human

Target Name

ACOD1

Target Full Name

Cis-aconitate decarboxylase

Target Function

Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation.

Target Subcellular Location

Mitochondrion.

Target Protein Families

PrpD family

Target Tissue Specificity

Expressed in LPS-tolerized macrophages (at protein level). Expressed in peripheral blood mononuclear cells (PBMCs), microglia and macrophage cells.

Target Research Area

Others

Target Synonyms

ACOD1; Aconitate decarboxylase 1; Aconitate decarboxylase; CAD; Cis aconitate decarboxylase; Immune responsive gene 1 protein homolog; Immune-responsive gene 1 protein homolog; Immunoresponsive 1 homolog (mouse); Irg1; IRG1_HUMAN; OC116; OPTB1; TCTIRC7