Recombinant Human Citron Rho-interacting kinase (CIT), Truncated

Uniprot Id

O14578

Target Species

Human

Target Name

CIT

Target Full Name

Citron Rho-interacting kinase

Target Function

Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.

Target Involvement

Microcephaly 17, primary, autosomal recessive (MCPH17)

Target Subcellular Location

Cytoplasm.

Target Protein Families

Protein kinase superfamily, AGC Ser/Thr protein kinase family

Target Synonyms

CIT; CRIK; KIAA0949; STK21Citron Rho-interacting kinase; CRIK; EC 2.7.11.1; Serine/threonine-protein kinase 21

Target Background

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants.