Recombinant Human Class E basic helix-loop-helix protein 22 (BHLHE22)

Uniprot Id

Q8NFJ8

Target Species

Human

Target Name

BHLHE22

Target Full Name

Class E basic helix-loop-helix protein 22

Target Function

Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA. In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Brain-specific, with the highest expression in the cerebellum.

Target Synonyms

Basic helix loop helix domain containing class B 5 1 2 5; Basic helix loop helix protein 5; Beta3; Beta3a; BHE22_HUMAN; bHLHB5; bHLHe22; CAGL85; Class B basic helix-loop-helix protein 5; Class E basic helix-loop-helix protein 22; Class II bHLH protein BHLHB5; TNRC20; Trinucleotide repeat containing 20; Trinucleotide repeat-containing gene 20 protein