Recombinant Human Clathrin coat assembly protein AP180 (SNAP91), Truncated

Uniprot Id

O60641

Target Species

Human

Target Name

SNAP91

Target Full Name

Clathrin coat assembly protein AP180

Target Function

Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats.

Target Subcellular Location

Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.

Target Protein Families

PICALM/SNAP91 family

Target Synonyms

SNAP91; KIAA0656Clathrin coat assembly protein AP180; 91 kDa synaptosomal-associated protein; Clathrin coat-associated protein AP180; Phosphoprotein F1-20

Target Background

Predicted to enable several functions, including SNARE binding activity; clathrin binding activity; and phosphatidylinositol binding activity. Acts upstream of or within regulation of clathrin-dependent endocytosis. Predicted to be located in several cellular components, including postsynaptic density; presynaptic endosome; and presynaptic membrane. Predicted to be extrinsic component of endosome membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; cytoplasmic vesicle; and parallel fiber to Purkinje cell synapse. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Biomarker of Alzheimer's disease.