Recombinant Human Claudin-11 (CLDN11), Truncated

Uniprot Id

O75508

Target Species

Human

Target Name

CLDN11

Target Full Name

Claudin-11

Target Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Target Subcellular Location

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Target Protein Families

Claudin family

Target Research Area

Immunology

Target Synonyms

CLDN11; OSP; OTM; Claudin-11; Oligodendrocyte-specific protein

Target Background

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.