Recombinant Human Claudin-7 (CLDN7), Truncated

Uniprot Id

O95471

Target Species

Human

Target Name

CLDN7

Target Full Name

Claudin-7

Target Function

Plays a major role in tight junction-specific obliteration of the intercellular space.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Cell junction, tight junction.

Target Protein Families

Claudin family

Target Tissue Specificity

Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (L

Target Synonyms

CLDN7; CEPTRL2; CPETRL2; Claudin-7; CLDN-7

Target Background

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.