Recombinant Human Claudin-8 (CLDN8), Truncated

Uniprot Id

P56748

Target Species

Human

Target Name

CLDN8

Target Full Name

Claudin-8

Target Function

Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Target Subcellular Location

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Target Protein Families

Claudin family

Target Tissue Specificity

Expressed in the epididymis, mainly in the caput segment.

Target Synonyms

CLDN8; UNQ779/PRO1573; Claudin-8

Target Background

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.