Recombinant Human Cleavage and polyadenylation specificity factor subunit 1 (CPSF1), Truncated

Uniprot Id

Q10570

Target Species

Human

Target Name

CPSF1

Target Full Name

Cleavage and polyadenylation specificity factor subunit 1

Target Function

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain.

Target Subcellular Location

Nucleus, nucleoplasm.

Target Protein Families

CPSF1 family

Target Tissue Specificity

Widely expressed, with high expression in the retina.

Target Synonyms

CPSF1; CPSF160Cleavage and polyadenylation specificity factor subunit 1; Cleavage and polyadenylation specificity factor 160 kDa subunit; CPSF 160 kDa subunit

Target Background

Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).