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Recombinant Human Coactosin-like protein (COTL1)

ACP17859

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Specifications

Cat.No	ACP17859	Target Name	COTL1
Target Synonyms	CLP; Coactosin like 1; Coactosin-like protein; COTL1; COTL1_HUMAN; FLJ43657; MGC19733	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	2-142
Protein Length	Full Length of Mature Protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q14019

Background Information

Uniprot Id

Q14019
Target Species

Human
Target Name

COTL1
Target Full Name

Coactosin-like protein
Target Function

Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.
Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
Target Protein Families

Actin-binding proteins ADF family, Coactosin subfamily
Target Tissue Specificity

Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.
Target Research Area

Signal Transduction
Target Synonyms

CLP; Coactosin like 1; Coactosin-like protein; COTL1; COTL1_HUMAN; FLJ43657; MGC19733
Target Background

This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.

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Recombinant Human Coactosin-like protein (COTL1)

Specifications

Immunogen Information

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