Recombinant Human Coatomer subunit alpha (COPA), Truncated

Uniprot Id

P53621

Target Species

Human

Target Name

COPA

Target Full Name

Coatomer subunit alpha

Target Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.; Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor

Target Involvement

Autoimmune interstitial lung, joint, and kidney disease (AILJK)

Target Subcellular Location

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.; [Xenin]: Secreted.

Target Tissue Specificity

Uniformly expressed in a wide range of adult and fetal tissues. Xenin is found in gastric, duodenal and jejunal mucosa. Circulates in the blood. Seems to be confined to specific endocrine cells.

Target Synonyms

Alpha coat protein; Alpha COP; Alpha COPI; Alpha-coat protein; Alpha-COP; AlphaCOP; Coatomer protein complex subunit alpha; Coatomer subunit alpha; COP A; COP I alpha; copA; COPA_HUMAN; COPI alpha; FLJ26320; HEP COP; HEP-COP; HEPCOP; Proxenin; Xenin; Xenopsin-related peptide