Recombinant Human Coatomer subunit delta (ARCN1)

Uniprot Id

P48444

Target Species

Human

Target Name

ARCN1

Target Full Name

Coatomer subunit delta

Target Function

Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors

Target Involvement

Short stature, rhizomelic, with microcephaly, micrognathia, and developmental delay (SRMMD)

Target Subcellular Location

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Target Protein Families

Adaptor complexes medium subunit family, Delta-COP subfamily

Target Tissue Specificity

Ubiquitously expressed.

Target Synonyms

Archain 1; Archain; Archain vesicle transport protein 1; Arcn1; Coatomer delta subunit; Coatomer protein complex, subunit delta; Coatomer protein delta COP; Coatomer subunit delta; COPD_HUMAN; Delta coat protein; Delta COP; Delta-coat protein; Delta-COP