Home Products Recombinant Human Coiled-coil domain-containing protein 65 (CCDC65)

Recombinant Human Coiled-coil domain-containing protein 65 (CCDC65)

ACP14978

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Specifications

Cat.No	ACP14978	Target Name	CCDC65
Target Synonyms	CCDC65; DRC2Dynein regulatory complex subunit 2; Coiled-coil domain-containing protein 65; Testis development protein NYD-SP28	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-484
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q8IXS2

Background Information

Uniprot Id

Q8IXS2
Target Species

Human
Target Name

CCDC65
Target Full Name

Dynein regulatory complex subunit 2
Target Function

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Target Involvement

Ciliary dyskinesia, primary, 27 (CILD27)
Target Subcellular Location

Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme.
Target Protein Families

DRC2 family
Target Tissue Specificity

Highly expressed in adult testis, in spermatocytes and spermatids. Also observed in spermatogonia. Not detected in Leydig cells, nor in fetal testis (at protein level).
Target Synonyms

CCDC65; DRC2Dynein regulatory complex subunit 2; Coiled-coil domain-containing protein 65; Testis development protein NYD-SP28

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Recombinant Human Coiled-coil domain-containing protein 65 (CCDC65)

Specifications

Immunogen Information

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