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| Cat.No | ACP14574 | Target Name | TERB1 |
|---|---|---|---|
| Target Synonyms | TERB1; CCDC79; Telomere repeats-binding bouquet formation protein 1; Coiled-coil domain-containing protein 79 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-727 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8NA31 |
|---|
Uniprot Id
Q8NA31
Target Species
Human
Target Name
TERB1
Target Full Name
Telomere repeats-binding bouquet formation protein 1
Target Function
Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.
Target Subcellular Location
Chromosome, telomere. Nucleus inner membrane.
Target Protein Families
TERB1 family
Target Synonyms
TERB1; CCDC79; Telomere repeats-binding bouquet formation protein 1; Coiled-coil domain-containing protein 79
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