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Expand your research possibilities in signal transduction with our premium Recombinant Human Complement C5 (C5) protein. Complement C5, encoded by the C5 gene, is a crucial component of the immune system's complement cascade, influencing a wide range of biological processes, including inflammation, cell lysis, and chemotaxis. This recombinant protein offers a partial representation of the human Complement C5, spanning the 678-751aa expression region. Expertly produced in E.coli, the protein is designed with an N-terminal 6xHis-SUMO tag for seamless purification and detection methods. Our Recombinant Human Complement C5 boasts a purity greater than 90%, as determined by SDS-PAGE, ensuring a high-quality product for your experiments. Available in both liquid and lyophilized powder forms, this protein offers versatility and convenience to researchers in the signal transduction field.
Expand your research possibilities in signal transduction with our premium Recombinant Human Complement C5 (C5) protein. Complement C5, encoded by the C5 gene, is a crucial component of the immune system’s complement cascade, influencing a wide range of biological processes, including inflammation, cell lysis, and chemotaxis.
This recombinant protein offers a partial representation of the human Complement C5, spanning the 678-751aa expression region. Expertly produced in E.coli, the protein is designed with an N-terminal 6xHis-SUMO tag for seamless purification and detection methods. Our Recombinant Human Complement C5 boasts a purity greater than 90%, as determined by SDS-PAGE, ensuring a high-quality product for your experiments. Available in both liquid and lyophilized powder forms, this protein offers versatility and convenience to researchers in the signal transduction field.
| Cat.No | ACP03403 | Target Name | C5 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 678-751aa | Mol Weight | 24.3kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P01031 |
|---|
Uniprot Id
P01031
Target Species
Human
Target Name
C5
Target Full Name
Complement C5
Target Function
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.; Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
Target Involvement
Complement component 5 deficiency (C5D)
Target Subcellular Location
Secreted.
Target Research Area
Signal Transduction
Target Synonyms
Anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5; C5a anaphylatoxin; C5a; C5b; CO5_HUMAN; Complement C5 alpha'' chain; Complement C5; Complement component C5; CPAMD4; prepro-C5
Target Background
This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants.
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