Recombinant Human Complement component C8 beta chain (C8B)

Uniprot Id

P07358

Target Species

Human

Target Name

C8B

Target Full Name

Complement component C8 beta chain

Target Function

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

Target Involvement

Complement component 8 deficiency, 2 (C8D2)

Target Subcellular Location

Secreted.

Target Protein Families

Complement C6/C7/C8/C9 family

Target Research Area

Cardiovascular

Target Synonyms

C8b; CO8B_HUMAN; Complement component 8 beta polypeptide; Complement component 8 subunit beta; Complement component C8 beta chain

Target Background

This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants.