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| Cat.No | ACP11215 | Target Name | COPRS |
|---|---|---|---|
| Target Synonyms | COPRS; C17orf79; COPR5Coordinator of PRMT5 and differentiation stimulator; Cooperator of PRMT5; Protein TTP1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-184 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NQ92 |
|---|
Uniprot Id
Q9NQ92
Target Species
Human
Target Name
COPRS
Target Full Name
Coordinator of PRMT5 and differentiation stimulator
Target Function
Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation
Target Subcellular Location
Nucleus.
Target Synonyms
COPRS; C17orf79; COPR5Coordinator of PRMT5 and differentiation stimulator; Cooperator of PRMT5; Protein TTP1
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