Recombinant Human COP9 signalosome complex subunit 1 (GPS1)

Uniprot Id

Q13098

Target Species

Human

Target Name

GPS1

Target Full Name

COP9 signalosome complex subunit 1

Target Function

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

CSN1 family

Target Tissue Specificity

Widely expressed.

Target Synonyms

COP9 signalosome complex subunit 1; COP9 signalosome subunit 1; COPS1; CSN 1; CSN1_HUMAN; FUS6/COP11; Arabidopsis; homolog of; G protein pathway suppressor 1; GPS-1; Gps1; JAB1-containing signalosome subunit 1; Protein GPS1; Protein MFH; SGN1; Signalosome subunit 1

Target Background

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells.