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Recombinant Human Corepressor interacting with RBPJ 1 (CIR1)

ACP15484

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Specifications

Cat.No	ACP15484	Target Name	CIR1
Target Synonyms	CIR1; CIRCorepressor interacting with RBPJ 1; CBF1-interacting corepressor; Recepin	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-450
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q86X95

Background Information

Uniprot Id

Q86X95
Target Species

Human
Target Name

CIR1
Target Full Name

Corepressor interacting with RBPJ 1
Target Function

May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
Target Subcellular Location

Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.
Target Tissue Specificity

Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.
Target Synonyms

CIR1; CIRCorepressor interacting with RBPJ 1; CBF1-interacting corepressor; Recepin
Target Background

Enables histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nuclear speck. Part of protein-containing complex. Colocalizes with centrosome.

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Recombinant Human Corepressor interacting with RBPJ 1 (CIR1)

Specifications

Immunogen Information

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