Recombinant Human Cornulin (CRNN)

Cat.No	ACP18892	Target Name	CRNN
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-495	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP18892

Target Name

CRNN

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-495

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9UBG3

Background Information

Uniprot Id

Q9UBG3
Target Species

Human
Target Name

CRNN
Target Full Name

Cornulin
Target Function

Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways.
Target Subcellular Location

Cytoplasm. Note=Does not colocalize with TGM1.
Target Protein Families

S100-fused protein family
Target Tissue Specificity

Expressed in the basal skin layer (at protein level). Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular l
Target Synonyms

53 kDa putative calcium binding protein; 53 kDa putative calcium-binding protein; 53 kDa squamous epithelial induced stress protein; 53 kDa squamous epithelial-induced stress protein; 58 kDa heat shock protein; C1orf10; Chromosome 1 open reading frame 10; Cornulin; CRNN; CRNN_HUMAN; DRC1; PDRC1; SEP53; Squamous epithelial heat shock protein 53; Tumor related protein; Tumor-related protein
Target Background

This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation.

Recombinant Human Cornulin (CRNN)

Specifications

Immunogen Information

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