Recombinant Human COUP transcription factor 2 (NR2F2)

Uniprot Id

P24468

Target Species

Human

Target Name

NR2F2

Target Full Name

COUP transcription factor 2

Target Function

Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development.

Target Involvement

Congenital heart defects, multiple types, 4 (CHTD4)

Target Subcellular Location

Nucleus.

Target Protein Families

Nuclear hormone receptor family, NR2 subfamily

Target Tissue Specificity

Ubiquitous. Expressed in the stromal cells of developing fetal ovaries.

Target Synonyms

Apolipoprotein A-I regulatory protein 1; Apolipoprotein AI regulatory protein 1; ARP-1; ARP1; COT2_HUMAN; COUP TF2; COUP transcription factor 2; COUP transcription factor II; COUP-TF II; COUP-TF2; NR2F2; Nuclear receptor subfamily 2 group F member 2

Target Background

This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants.