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| Cat.No | ACP21387 | Target Name | CTDSPL |
|---|---|---|---|
| Target Synonyms | C3orf8; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; CTD (carboxy-terminal domain, RNA polymerase II | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-276 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O15194 |
|---|
Uniprot Id
O15194
Target Species
Human
Target Name
CTDSPL
Target Full Name
CTD small phosphatase-like protein
Target Function
Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.
Target Subcellular Location
Nucleus.
Target Tissue Specificity
Expression is restricted to non-neuronal tissues.
Target Synonyms
C3orf8; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; CTD small phosphatase-like protein; CTDSL_HUMAN; CTDSP-like; Ctdspl; hYA22; N-like protein; NIF-like protein; NLI-interacting factor 1; Nuclear LIM interactor-interacting factor 1; Protein YA22; RB protein serine phosphatase from chromosome 3; RBSP3; SCP3; Small C-terminal domain phosphatase 3; Small CTD phosphatase 3
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