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The intact gene sequence encoding the human CTP synthase 1 (CTPS1) is expressed in the yeast. The resulting protein is fused with the 6xHis-tag to generate the recombinant human CTPS1 protein. Its purity reaches up to 90% measured by SDS-PAGE. On the gel, this recombinant CTPS1 protein migrated to the molecular weight band of about 70 kDa. The observed molecular weight is a little greater than the theoretical value due to the galactosylated modification. The target protein CTPS1 catalyzes the rate-limiting step in the de novo synthesis of CTP. It is important for the expansion of activated T cells. In T lymphocytes, CTPS1 expression is upregulated in response to TCR stimulation.
The intact gene sequence encoding the human CTP synthase 1 (CTPS1) is expressed in the yeast. The resulting protein is fused with the 6xHis-tag to generate the recombinant human CTPS1 protein. Its purity reaches up to 90% measured by SDS-PAGE. On the gel, this recombinant CTPS1 protein migrated to the molecular weight band of about 70 kDa. The observed molecular weight is a little greater than the theoretical value due to the galactosylated modification. The target protein CTPS1 catalyzes the rate-limiting step in the de novo synthesis of CTP. It is important for the expansion of activated T cells. In T lymphocytes, CTPS1 expression is upregulated in response to TCR stimulation.
| Cat.No | ACP04825 | Target Name | CTPS1 |
|---|---|---|---|
| Target Synonyms | CTPS1; CTPS; CTP synthase 1; EC 6.3.4.2; CTP synthetase 1; UTP--ammonia ligase 1 | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 1-591aa |
| Mol Weight | 68.7kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P17812 |
|---|
Uniprot Id
P17812
Target Species
Human
Target Name
CTPS1
Target Full Name
CTP synthase 1
Target Function
This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.
Target Involvement
Immunodeficiency 24 (IMD24)
Target Subcellular Location
Cytoplasm, cytosol.
Target Protein Families
CTP synthase family
Target Tissue Specificity
Widely expressed.
Target Research Area
Signal Transduction
Target Synonyms
CTPS1; CTPS; CTP synthase 1; EC 6.3.4.2; CTP synthetase 1; UTP--ammonia ligase 1
Target Background
This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants.
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