Recombinant Human CTP synthase 1 (CTPS1)

Uniprot Id

P17812

Target Species

Human

Target Name

CTPS1

Target Full Name

CTP synthase 1

Target Function

This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.

Target Involvement

Immunodeficiency 24 (IMD24)

Target Subcellular Location

Cytoplasm, cytosol.

Target Protein Families

CTP synthase family

Target Tissue Specificity

Widely expressed.

Target Research Area

Signal Transduction

Target Synonyms

CTPS1; CTPS; CTP synthase 1; EC 6.3.4.2; CTP synthetase 1; UTP--ammonia ligase 1

Target Background

This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants.