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| Cat.No | ACP16493 | Target Name | CXXC5 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-322 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q7LFL8 |
|---|
Uniprot Id
Q7LFL8
Target Species
Human
Target Name
CXXC5
Target Full Name
CXXC-type zinc finger protein 5
Target Function
May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ. Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG.
Target Subcellular Location
Nucleus. Cytoplasm.
Target Synonyms
CF5; CXXC finger 5 protein; CXXC finger protein 5; CXXC-type zinc finger protein 5; CXXC5; CXXC5_HUMAN; HSPC195; Putative MAPK-activating protein PM08; Putative NF-kappa-B-activating protein 102; retinoid-inducible nuclear factor; RINF; TCCCIA00297; WID; WT1-induced Inhibitor of Dishevelled
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