Recombinant Human Cyclic nucleotide-gated cation channel beta-3 (CNGB3), Truncated

Uniprot Id

Q9NQW8

Target Species

Human

Target Name

CNGB3

Target Full Name

Cyclic nucleotide-gated channel beta-3

Target Function

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.

Target Involvement

Stargardt disease 1 (STGD1); Achromatopsia 3 (ACHM3)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGB3 subfamily

Target Tissue Specificity

Expressed specifically in the retina.

Target Synonyms

ACHM1; ACHM3; Achromatopsia (rod monochromacy) 3; CNG channel beta-3; CNGB3; CNGB3_HUMAN; Cone photoreceptor cGMP-gated cation channel beta-subunit; Cone photoreceptor cGMP-gated channel subunit beta; Cyclic nucleotide gated channel beta 3; Cyclic nucleotide-gated cation channel beta-3; Cyclic nucleotide-gated cation channel modulatory subunit; Cyclic nucleotide-gated channel beta-3; RMCH; RMCH1