Recombinant Human Cyclin-T2 (CCNT2)

Uniprot Id

O60583

Target Species

Human

Target Name

CCNT2

Target Full Name

Cyclin-T2

Target Function

Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). The activity of this complex is regulated by binding with 7SK snRNA. Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II. In addition, enhances MYOD1-dependent transcription through interaction with PKN1. Involved in early embryo development.; (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters

Target Subcellular Location

Cytoplasm, perinuclear region. Nucleus.

Target Protein Families

Cyclin family, Cyclin C subfamily

Target Tissue Specificity

Ubiquitously expressed.

Target Synonyms

CCNT2; CCNT2_HUMAN; Cyclin T2a; Cyclin T2b; Cyclin-T2; CycT2; FLJ90560; MGC134840; SDS stable vimentin bound DNA fragment HEF42VIM22; Subunit of positive elongation transcription factor b