Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
Amino acids 2-551 form the expressed segment for recombinant Human CBS. This CBS protein is theoretically predicted to have a molecular weight of 64.5 kDa. Expression of this CBS protein is conducted in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of CBS, making it easier to detect and purify the CBS recombinant protein in the later stages of expression and purification.Cystathionine beta-synthase (CBS) is a crucial enzyme primarily involved in the metabolic pathway of homocysteine. One of its most popular and critical research areas focuses on its regulatory role in metabolism and diseases. CBS plays a key role in sulfur amino acid metabolism, participating in the conversion between cysteine and homocysteine, thereby influencing the body's sulfur metabolism balance. Recent studies have shown a widespread interest in the association of CBS with significant diseases, particularly cardiovascular diseases related to hyperhomocysteinemia. Elevated homocysteine levels are closely linked to atherosclerosis and cardiovascular diseases, making CBS a hot topic in research as an essential regulatory factor in this pathway. Additionally, CBS is implicated in various physiological and pathological processes related to the nervous system, tumors, and more. In the nervous system, CBS plays a role in neurotransmitter synthesis and oxidative stress response, garnering attention in the study of diseases associated with the nervous system. In the field of tumors, some studies suggest CBS's involvement in the proliferation and survival mechanisms of tumor cells, providing a new perspective for understanding cancer development.
Amino acids 2-551 form the expressed segment for recombinant Human CBS. This CBS protein is theoretically predicted to have a molecular weight of 64.5 kDa. Expression of this CBS protein is conducted in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of CBS, making it easier to detect and purify the CBS recombinant protein in the later stages of expression and purification.Cystathionine beta-synthase (CBS) is a crucial enzyme primarily involved in the metabolic pathway of homocysteine. One of its most popular and critical research areas focuses on its regulatory role in metabolism and diseases. CBS plays a key role in sulfur amino acid metabolism, participating in the conversion between cysteine and homocysteine, thereby influencing the body’s sulfur metabolism balance. Recent studies have shown a widespread interest in the association of CBS with significant diseases, particularly cardiovascular diseases related to hyperhomocysteinemia. Elevated homocysteine levels are closely linked to atherosclerosis and cardiovascular diseases, making CBS a hot topic in research as an essential regulatory factor in this pathway. Additionally, CBS is implicated in various physiological and pathological processes related to the nervous system, tumors, and more. In the nervous system, CBS plays a role in neurotransmitter synthesis and oxidative stress response, garnering attention in the study of diseases associated with the nervous system. In the field of tumors, some studies suggest CBS’s involvement in the proliferation and survival mechanisms of tumor cells, providing a new perspective for understanding cancer development.
| Cat.No | ACP03107 | Target Name | CBS |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-551aa | Mol Weight | 64.5kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P35520 |
|---|
Uniprot Id
P35520
Target Species
Human
Target Name
CBS
Target Full Name
Cystathionine beta-synthase
Target Function
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.
Target Involvement
Cystathionine beta-synthase deficiency (CBSD)
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Cysteine synthase/cystathionine beta-synthase family
Target Tissue Specificity
In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney.
Target Research Area
Metabolism
Target Synonyms
AI047524; AI303044; Beta thionase; Beta-thionase; Cbs; Cbs cystathionine beta-synthase; CBS_HUMAN; Cystathionine beta synthase; Cystathionine beta-synthase; EC 4.2.1.22; HIP 4; HIP4; Methylcysteine synthase; MGC18856; MGC18895; MGC37300; OTTHUMP00000109416; OTTHUMP00000109418; Serine sulfhydrase
Target Background
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
