Recombinant Human Cytochrome b-245 light chain (CYBA)

Uniprot Id

P13498

Target Species

Human

Target Name

CYBA

Target Full Name

Cytochrome b-245 light chain

Target Function

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.

Target Involvement

Granulomatous disease, chronic, cytochrome-b-negative, autosomal recessive (ARCGD)

Target Subcellular Location

Cell membrane.

Target Protein Families

P22phox family

Target Synonyms

CYBACytochrome b-245 light chain; Cytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox; p22phox

Target Background

Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.