Recombinant Human Cytochrome P450 2C9 (CYP2C9)

Cat.No	ACP05053	Target Name	CYP2C9
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-162aa	Mol Weight	25.4 kDa
Protein Length	Full Length of Isoform 2	Purity	Greater than 85% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP05053

Target Name

CYP2C9

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-162aa

Mol Weight

25.4 kDa

Protein Length

Full Length of Isoform 2

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P11712

Background Information

Uniprot Id

P11712
Target Species

Human
Target Name

CYP2C9
Target Full Name

Cytochrome P450 2C9
Target Function

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2. Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol. Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Target Subcellular Location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Target Protein Families

Cytochrome P450 family
Target Research Area

Others
Target Synonyms

(R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CP2C9_HUMAN; CPC9; CYP2C; CYP2C10; CYP2C9; CYPIIC9; cytochrome P-450 S-mephenytoin 4-hydroxylase; Cytochrome P-450MP; Cytochrome P450 2C9; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P450 PB-1; Cytochrome P450; family 2; subfamily C; polypeptide 9; Cytochrome p4502C9; flavoprotein-linked monooxygenase; MGC149605; MGC88320; microsomal monooxygenase; OTTHUMP00000020135; P450 MP; P450 PB 1; P450 PB1; P450IIC9; P450MP; S mephenytoin 4 hydroxylase; S-mephenytoin 4-hydroxylase; xenobiotic monooxygenase

Recombinant Human Cytochrome P450 2C9 (CYP2C9)

Specifications

Immunogen Information

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