Recombinant Human Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1), Truncated

Uniprot Id

Q14204

Target Species

Human

Target Name

DYNC1H1

Target Full Name

Cytoplasmic dynein 1 heavy chain 1

Target Function

Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression.

Target Involvement

Charcot-Marie-Tooth disease 2O (CMT2O); Mental retardation, autosomal dominant 13 (MRD13); Spinal muscular atrophy, lower extremity-predominant 1, autosomal dominant (SMALED1)

Target Subcellular Location

Cytoplasm, cytoskeleton.

Target Protein Families

Dynein heavy chain family

Target Synonyms

DYNC1H1; DHC1; DNCH1; DNCL; DNECL; DYHC; KIAA0325Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; Dynein heavy chain; cytosolic

Target Background

Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family.