Recombinant Human Cytoplasmic dynein 1 intermediate chain 1 (DYNC1I1)

Uniprot Id

O14576

Target Species

Human

Target Name

DYNC1I1

Target Full Name

Cytoplasmic dynein 1 intermediate chain 1

Target Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.

Target Subcellular Location

Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.

Target Protein Families

Dynein intermediate chain family

Target Research Area

Signal Transduction

Target Synonyms

Cytoplasmic dynein 1 intermediate chain 1; Cytoplasmic dynein intermediate chain 1; cytosolic; DC1I1_HUMAN; DH IC 1; DH IC-1; DH IC1; DNCI1; DNCIC1; Dync1i1; Dynein cytoplasmic 1 intermediate chain 1; Dynein intermediate chain 1; Dynein intermediate chain 1; cytosolic; Dynein; cytoplasmic; intermediate polypeptide 1

Target Background

Enables spectrin binding activity. Involved in vesicle transport along microtubule. Located in several cellular components, including kinetochore; recycling endosome; and spindle pole.