Recombinant Human Cytoplasmic dynein 1 intermediate chain 2 (DYNC1I2)

Uniprot Id

Q13409

Target Species

Human

Target Name

DYNC1I2

Target Full Name

Cytoplasmic dynein 1 intermediate chain 2

Target Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.

Target Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm.

Target Protein Families

Dynein intermediate chain family

Target Synonyms

Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; cytosolic; DC1I2_HUMAN; DH IC 2 ; DH IC-2; DNCI2 ; DNCIC2 ; Dync1i2; Dynein intermediate chain 2; Dynein intermediate chain 2; cytosolic; Dynein; cytoplasmic; intermediate polypeptide 2 ; IC2

Target Background

This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants.