Recombinant Human Cytoplasmic dynein 2 light intermediate chain 1 (DYNC2LI1)

Cat.No	ACP03253	Target Name	DYNC2LI1
Target Synonyms	CGI-60; Cytoplasmic dynein 2 light intermediate chain 1; D2LIC; DC2L1_HUMAN; DYNC2LI1; Dynein 2 light intermediate chain; Dynein, cytoplasmic 2, light intermediate chain 1; LIC3	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	1-352aa
Mol Weight	44.8kDa	Protein Length	Full Length of Isoform 2
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03253

Target Name

DYNC2LI1

Target Synonyms

CGI-60; Cytoplasmic dynein 2 light intermediate chain 1; D2LIC; DC2L1_HUMAN; DYNC2LI1; Dynein 2 light intermediate chain; Dynein, cytoplasmic 2, light intermediate chain 1; LIC3

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-352aa

Mol Weight

44.8kDa

Protein Length

Full Length of Isoform 2

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q8TCX1

Background Information

Uniprot Id

Q8TCX1
Target Species

Human
Target Name

DYNC2LI1
Target Full Name

Cytoplasmic dynein 2 light intermediate chain 1
Target Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles. Involved in the regulation of ciliary length.
Target Involvement

Short-rib thoracic dysplasia 15 with polydactyly (SRTD15)
Target Subcellular Location

Golgi apparatus. Cytoplasm. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Target Protein Families

Dynein light intermediate chain family
Target Tissue Specificity

Expressed in bone, brain, kidney, and cartilage. Lower expression in heart, liver, lung, placenta and thymus.
Target Research Area

Signal Transduction
Target Synonyms

CGI-60; Cytoplasmic dynein 2 light intermediate chain 1; D2LIC; DC2L1_HUMAN; DYNC2LI1; Dynein 2 light intermediate chain; Dynein, cytoplasmic 2, light intermediate chain 1; LIC3
Target Background

This gene encodes a protein that is a component of the dynein-2 microtubule motor protein complex that plays a role in the retrograde transport of cargo in primary cilia via the intraflagellar transport system. This gene is ubiquitously expressed and its protein, which localizes to the axoneme and Golgi apparatus, interacts directly with the cytoplasmic dynein 2 heavy chain 1 protein to form part of the multi-protein dynein-2 complex. Mutations in this gene produce defects in the dynein-2 complex which result in several types of ciliopathy including short-rib thoracic dysplasia 15 with polydactyly (SRTD15). Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Recombinant Human Cytoplasmic dynein 2 light intermediate chain 1 (DYNC2LI1)

Specifications

Immunogen Information

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