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| Cat.No | ACP20869 | Target Name | ALDH1L1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O75891 |
|---|
Uniprot Id
O75891
Target Species
Human
Target Name
ALDH1L1
Target Full Name
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Target Subcellular Location
Cytoplasm.
Target Protein Families
GART family; Aldehyde dehydrogenase family, ALDH1L subfamily
Target Tissue Specificity
Highly expressed in liver, pancreas and kidney.
Target Synonyms
10 formyltetrahydrofolate dehydrogenase; 10 FTHFDH; 10-formyltetrahydrofolate dehydrogenase; 10-FTHFDH; AL1L1_HUMAN; Aldehyde dehydrogenase 1 family member L1; Aldehyde dehydrogenase family 1 member L1; aldh1l1; Cytosolic 10-formyltetrahydrofolate dehydrogenase; DKFZp781N0997; EC 1.5.1.6; FDH; formyltetrahydrofolate dehydrogenase; FTHFD; OTTHUMP00000155221; OTTHUMP00000214696; OTTHUMP00000214700; OTTHUMP00000222724
Target Background
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants.
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