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| Cat.No | ACP13306 | Target Name | CASTOR1 |
|---|---|---|---|
| Target Synonyms | GATL3_HUMAN; GATS-like protein 3; GATSL3 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-329 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8WTX7 |
|---|
Uniprot Id
Q8WTX7
Target Species
Human
Target Name
CASTOR1
Target Full Name
Cytosolic arginine sensor for mTORC1 subunit 1
Target Function
Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
Target Subcellular Location
Cytoplasm, cytosol.
Target Protein Families
GATS family
Target Tissue Specificity
Widely expressed.
Target Synonyms
GATL3_HUMAN; GATS-like protein 3; GATSL3
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