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The recombinant Human DRD1 protein expression involves transfecting e.coli cells with a DNA expression vector containing the gene encoding the recombinant protein of interest (338-446aa) and then culturing the cells so that they express the desired protein. The protein features a N-terminal 6xHis tag fusion. The recombinant Human DRD1 protein is collected and purified from the cell lysate through affinity purification. Its purity is greater than 90%, as measured by SDS-PAGE.
The recombinant Human DRD1 protein expression involves transfecting e.coli cells with a DNA expression vector containing the gene encoding the recombinant protein of interest (338-446aa) and then culturing the cells so that they express the desired protein. The protein features a N-terminal 6xHis tag fusion. The recombinant Human DRD1 protein is collected and purified from the cell lysate through affinity purification. Its purity is greater than 90%, as measured by SDS-PAGE.
| Cat.No | ACP01921 | Target Name | DRD1 |
|---|---|---|---|
| Target Synonyms | DRD1; D(1A dopamine receptor; Dopamine D1 receptor | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 338-446aa |
| Mol Weight | 17.8 kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P21728 |
|---|
Uniprot Id
P21728
Target Species
Human
Target Name
DRD1
Target Full Name
D(1A) dopamine receptor
Target Function
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine.
Target Protein Families
G-protein coupled receptor 1 family
Target Tissue Specificity
Detected in caudate, nucleus accumbens and in the olfactory tubercle.
Target Research Area
Neuroscience
Target Synonyms
DRD1; D(1A dopamine receptor; Dopamine D1 receptor
Target Background
This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.
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