Recombinant Human D (2) dopamine receptor (DRD2), Truncated

Uniprot Id

P14416

Target Species

Human

Target Name

DRD2

Target Full Name

D(2) dopamine receptor

Target Function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.

Target Protein Families

G-protein coupled receptor 1 family

Target Tissue Specificity

[Isoform 1]: Expressed in the anterior pituitary gland.; [Isoform 2]: Expressed in the anterior pituitary gland.

Target Research Area

G-protein coupled receptor, Receptor, Transducer

Target Synonyms

DRD2; D(2 dopamine receptor; Dopamine D2 receptor

Target Background

This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.