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| Cat.No | ACP14801 | Target Name | DTD1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-209 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8TEA8 |
|---|
Uniprot Id
Q8TEA8
Target Species
Human
Target Name
DTD1
Target Full Name
D-aminoacyl-tRNA deacylase 1
Target Function
Possible ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes.; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
Target Subcellular Location
Nucleus. Cytoplasm. Note=Associated with chromatin at some replication origins containing functional DNA-unwinding elements (PubMed:20065034).
Target Protein Families
DTD family
Target Tissue Specificity
Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain.
Target Synonyms
bA379J5.3; bA555E18.1; C20orf88; D tyrosyl tRNA deacylase 1 homolog; D-tyrosyl-tRNA(Tyr) deacylase 1; DNA unwinding element binding protein; DTD1; DTD1_HUMAN; DUE B; DUEB; HARS2; Histidyl tRNA synthetase 2; Histidyl-tRNA synthase-related; MGC119131; MGC41905; pqn 68
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