Recombinant Human DDB1- and CUL4-associated factor 12 (DCAF12)

Uniprot Id

Q5T6F0

Target Species

Human

Target Name

DCAF12

Target Full Name

DDB1- and CUL4-associated factor 12

Target Function

Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6 and CCT5, leading to their ubiquitination and degradation. Ubiquitination of MAGEA3, MAGEA6 by DCX(DCAF12) complex is required for starvation-induced autophagy

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Target Protein Families

WD repeat DCAF12 family

Target Tissue Specificity

Highly expressed in lung cancer tissues and some cancer cell lines. Restricted expression in normal testis.

Target Synonyms

cancer/testis antigen 102; Centrosome-related protein TCC52; CT102; DCA12_HUMAN; DCAF12; DDB1- and CUL4-associated factor 12; DKFZP434O125; KIAA1892; MGC1058; TCC52; Testis cancer centrosome-related protein; WD repeat domain 40A; WD repeat-containing protein 40A; WDR40A