Recombinant Human Death ligand signal enhancer (KIAA0141)

Uniprot Id

Q14154

Target Species

Human

Target Name

DELE1

Target Full Name

DAP3-binding cell death enhancer 1

Target Function

Key activator of the integrated stress response (ISR) following mitochondrial stress. In response to mitochondrial stress, cleaved by the protease OMA1, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR. Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.; Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI. It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR

Target Subcellular Location

[DAP3-binding cell death enhancer 1]: Mitochondrion. Mitochondrion inner membrane.; [DAP3-binding cell death enhancer 1 short form]: Cytoplasm, cytosol.

Target Tissue Specificity

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Target Synonyms

DELE1; DELE; KIAA0141DAP3-binding cell death enhancer 1; Death ligand signal enhancer