Recombinant Human Dedicator of cytokinesis protein 7 (DOCK7), Truncated

Uniprot Id

Q96N67

Target Species

Human

Target Name

DOCK7

Target Full Name

Dedicator of cytokinesis protein 7

Target Function

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3.

Target Involvement

Epileptic encephalopathy, early infantile, 23 (EIEE23)

Target Subcellular Location

Cell projection, axon. Note=Enriched in the developing axons of hippocampal neurons.

Target Protein Families

DOCK family

Target Tissue Specificity

Widely expressed.

Target Synonyms

DOCK7; KIAA1771Dedicator of cytokinesis protein 7

Target Background

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene.