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| Cat.No | ACP11649 | Target Name | DMBT1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9UGM3 |
|---|
Uniprot Id
Q9UGM3
Target Species
Human
Target Name
DMBT1
Target Full Name
Scavenger receptor cysteine-rich domain-containing protein DMBT1
Target Function
May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.
Target Involvement
Glioma (GLM)
Target Subcellular Location
Secreted.
Target Protein Families
DMBT1 family
Target Tissue Specificity
Highly expressed in alveolar and macrophage tissues. In some macrophages, expression is seen on the membrane, and in other macrophages, strongly expressed in the phagosome/phagolysosome compartments. Expressed in lung, trachea, salivary gland, small intes
Target Synonyms
Apactin; CRP; CRP-[a]; CRP-[b]; CRP-ductin; Crpd; DBMT1; Deleted in malignant brain tumors 1; Deleted in malignant brain tumors 1 protein; DMBT 1; DMBT1; DMBT1 prototype precursor; DMBT1/6kb.1 protein precursor; DMBT1/8kb.1 protein; DMBT1/8kb.2 protein precursor; DMBT1_HUMAN; Ebnerin; FLJ61058; Glycoprotein 300; Glycoprotein 340; Gp 340; Gp-340; gp300; GP340; Gp340 variant protein; Hensin; MGC164738; Mucin-like glycoprotein; Muclin; OTTHUMP00000020654; OTTHUMP00000020655; OTTHUMP00000020656; OTTHUMP00000020657; OTTHUMP00000020658; OTTHUMP00000020659; OTTHUMP00000020660; OTTHUMP00000020661; OTTHUMP00000020662; OTTHUMP00000020663; p80; Pancrin; SAG; Salivary agglutinin; Surfactant pulmonary associated D binding protein; Surfactant pulmonary associated protein D binding protein; Surfactant pulmonary-associated D-binding protein; Vomeroglandin
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