Recombinant Human Delta-like protein 3 (DLL3), Truncated

Uniprot Id

Q9NYJ7

Target Species

Human

Target Name

DLL3

Target Full Name

Delta-like protein 3

Target Function

Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.

Target Involvement

Spondylocostal dysostosis 1, autosomal recessive (SCDO1)

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Research Area

Developmental Biology

Target Synonyms

Delta Drosophila like 3; Delta like 3 Drosophila; Delta like 3 homolog Drosophila; Delta like 3 protein; Delta like protein 3 precursor; Delta-like protein 3; Delta3; Dll3; DLL3_HUMAN; Drosophila Delta homolog 3; SCDO1; SCOD1; Spondylocostal dysostosis autosomal recessive

Target Background

This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.